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"news": [
{
"title": "Reported Sunday, Spyre Shows Anti-α4β7, Anti-TL1A And Anti-IL-23 Antibodies Each Efficacious In Humanized Mouse Colitis Model, With Combinations Further Improving Efficacy, At UEGW 2026",
"url": "https://www.benzinga.com/news/26/10/62431027/reported-sunday-spyre-shows-anti-4-7-anti-tl1a-and-anti-il-23-antibodies-each-efficacious-humanized-",
"source": "benzinga",
"date": "2026-10-19T06:54:29.347000+00:00",
"summary": "",
"image": ""
},
{
"title": "Spyre presents clinical data on IBD antibody therapies By Investing.com",
"url": "https://www.investing.com/news/company-news/spyre-presents-clinical-data-on-ibd-antibody-therapies-93CH-4955924",
"source": "Investing.com",
"date": "2026-10-18T13:36:36Z",
"summary": "BARCELONA - Spyre Therapeutics Inc. (NASDAQ:SYRE) presented clinical data on three inflammatory bowel disease antibody therapies at United European Gastroenterology Week 2026, according to a press release statement.\n\nThe company presented data on SPY001 (anti-α4β7), SPY002 (anti-",
"image": "https://content-media.investing.com/news/LYNXMPEM0J0ZC_1200_L.jpg"
},
{
"title": "Spyre Therapeutics Announces Clinical and Preclinical Data Presentations at United European Gastroenterology Week (UEGW) 2026",
"url": "https://www.globenewswire.com/news-release/2026/10/18/3382917/0/en/spyre-therapeutics-announces-clinical-and-preclinical-data-presentations-at-united-european-gastroenterology-week-uegw-2026.html",
"source": "GlobeNewswire Inc.",
"date": "2026-10-18T13:30:00Z",
"summary": "Spyre Therapeutics announced presentations of clinical and preclinical data for its three IBD antibodies (SPY001, SPY002, and SPY003) at UEGW 2026 in Barcelona. The company presented efficacy and safety data for these half-life extended antibodies in moderately to severely active",
"image": "https://ml.globenewswire.com/Resource/Download/bc26a912-b583-43c6-8423-55a4ba2bf4bd"
},
{
"title": "Why is Spyre Therapeutics stock rallying today? By Investing.com",
"url": "https://www.investing.com/news/stock-market-news/why-is-spyre-therapeutics-stock-rallying-today-93CH-4941369",
"source": "Investing.com",
"date": "2026-10-09T14:18:12Z",
"summary": "Investing.com -- Spyre Therapeutics stock rose 4.4% in morning trading as shares bounced back from the dilution-driven selldown that followed the company's recently closed $350 million public offering, with the stock now trading below the deal's $85-per-share pricing and drawing ",
"image": "https://content-media.investing.com/news/SP500StandardandPoors500Index_800x533_L_1657544297.jpg"
},
{
"title": "Spyre: Maintain 'Strong Buy' On Additional SPY072 Shots On Goal Q4 2026 And IBD Combination Potential",
"url": "https://seekingalpha.com/article/4952578-spyre-additional-spy072-shots-on-goal-q4-2026-and-ibd-combination-potential",
"source": "Seeking Alpha",
"date": "2026-10-07 14:18:57",
"summary": "Spyre Therapeutics maintains a 'Strong Buy' rating, driven by promising IBD pipeline progress and robust cash reserves. SYRE's three monotherapy candidates—SPY001, SPY002, SPY003—show potential best-in-class efficacy for IBD, with combination data expected in 2027. Despite discon",
"image": "https://images.financialmodelingprep.com/news/spyre-maintain-strong-buy-on-additional-spy072-shots-on-20261007.jpg"
},
{
"title": "Spyre Therapeutics Announces Pricing of $350.0 Million Public Offering of Common Stock",
"url": "https://www.globenewswire.com/news-release/2026/10/06/3375081/0/en/spyre-therapeutics-announces-pricing-of-350-0-million-public-offering-of-common-stock.html",
"source": "GlobeNewswire Inc.",
"date": "2026-10-06T00:13:00Z",
"summary": "Spyre Therapeutics priced its underwritten public offering at $85 per share, raising approximately $350 million in gross proceeds. The company plans to use the funds to advance its immunology programs in gastroenterology, rheumatology, and dermatology, including Phase 3 readiness",
"image": "https://ml.globenewswire.com/Resource/Download/bc26a912-b583-43c6-8423-55a4ba2bf4bd"
},
{
"title": "Why is Spyre Therapeutics stock sliding today? By Investing.com",
"url": "https://www.investing.com/news/stock-market-news/why-is-spyre-therapeutics-stock-sliding-today-93CH-4932986",
"source": "Investing.com",
"date": "2026-10-05T21:44:50Z",
"summary": "Investing.com -- Spyre Therapeutics Inc stock slid 4.0% in after-hours trading today after the clinical-stage biotechnology company announced the launch of an underwritten public offering of its common stock, sending shares to trade at $89.00 from a previous close of $92.72. The ",
"image": "https://content-media.investing.com/news/SP500StandardandPoors500Index_800x533_L_1657544297.jpg"
},
{
"title": "Spyre Therapeutics stock falls on public offering launch By Investing.com",
"url": "https://www.investing.com/news/stock-market-news/spyre-therapeutics-stock-falls-on-public-offering-launch-4932850",
"source": "Investing.com",
"date": "2026-10-05T20:16:22Z",
"summary": "Investing.com -- Spyre Therapeutics Inc (NASDAQ:SYRE) shares fell 2.9% in after-hours trading Monday following the company's announcement of an underwritten public offering of its common stock.\n\nThe clinical-stage biotechnology company said it has commenced the offering on Nasdaq",
"image": "https://content-media.investing.com/news/LYNXMPEM502AK_1200_L.jpg"
},
{
"title": "Spyre (NASDAQ: SYRE) legal chief trims stake in planned share sale",
"url": "https://www.defenseworld.net/2026/10/04/spyre-nasdaq-syre-legal-chief-trims-stake-in-planned-share-sale.html",
"source": "Defense World",
"date": "2026-10-04 09:02:56",
"summary": "What happened Spyre Therapeutics, Inc. (NASDAQ: SYRE) Chief Legal Officer and Corporate Secretary Heidy King-Jones sold 28,933 shares on 2026-10-01. The Form 4 shows five sale blocks at weighted-average prices from $89.24 to $93.46 per share, totaling about $2.63 million. It also",
"image": "https://images.financialmodelingprep.com/news/spyre-nasdaq-syre-legal-chief-trims-stake-in-planned-20261004.jpg"
},
{
"title": "Spyre Therapeutics' chief legal officer sells $2.63m in shares By Investing.com",
"url": "https://www.investing.com/news/insider-trading-news/spyre-therapeutics-chief-legal-officer-sells-263m-in-shares-93CH-4930743",
"source": "Investing.com",
"date": "2026-10-03T03:30:59Z",
"summary": "Heidy King-Jones, Chief Legal Officer and Corporate Secretary at Spyre Therapeutics, Inc. (NASDAQ:SYRE), sold shares totaling approximately $2,633,901 on October 1, 2026. The sales involved 28,933 shares of common stock at prices ranging between $89.24 and $93.46 per share. The s",
"image": "https://content-media.investing.com/news/moved_LYNXMPEM3Q0V4_1200_L.jpg"
},
{
"title": "Spyre Therapeutics CFO Scott Burrows sells $2.26m in stock By Investing.com",
"url": "https://www.investing.com/news/insider-trading-news/spyre-therapeutics-cfo-scott-burrows-sells-226m-in-stock-93CH-4930687",
"source": "Investing.com",
"date": "2026-10-03T02:01:31Z",
"summary": "Scott L. Burrows, Chief Financial Officer of Spyre Therapeutics, Inc. (NASDAQ:SYRE), reported significant stock transactions in a recent SEC Form 4 filing. Burrows sold a total of 25,000 shares of common stock for approximately $2.26 million across September 30 and October 1, 202",
"image": "https://content-media.investing.com/news/moved_LYNXMPEM3S10Z_1200_L.jpg"
},
{
"title": "Spyre Therapeutics CEO Cameron Turtle sells $1.38m in SYRE stock By Investing.com",
"url": "https://www.investing.com/news/insider-trading-news/spyre-therapeutics-ceo-cameron-turtle-sells-138m-in-syre-stock-93CH-4930685",
"source": "Investing.com",
"date": "2026-10-03T02:01:10Z",
"summary": "Cameron Turtle, Chief Executive Officer and a Director at Spyre Therapeutics, Inc. (NASDAQ:SYRE), sold 14,000 shares of the company's common stock on October 1, 2026. The transactions totaled approximately $1,380,104, with shares sold at weighted average prices ranging from $89.1",
"image": "https://content-media.investing.com/news/moved_LYNXMPEM4416N_1200_L.jpg"
},
{
"title": "Spyre Therapeutics (NASDAQ:SYRE) Shares Gap Up – Should You Buy?",
"url": "https://www.defenseworld.net/2026/10/02/spyre-therapeutics-nasdaqsyre-shares-gap-up-should-you-buy.html",
"source": "Defense World",
"date": "2026-10-02 05:41:13",
"summary": "Spyre Therapeutics, Inc. (NASDAQ: SYRE - Get Free Report)'s stock price gapped up prior to trading on Wednesday. The stock had previously closed at $84.72, but opened at $88.64. Spyre Therapeutics shares last traded at $90.4130, with a volume of 259,548 shares trading hands. Anal",
"image": "https://images.financialmodelingprep.com/news/spyre-therapeutics-nasdaqsyre-shares-gap-up-should-you-buy-20261002.jpg"
},
{
"title": "'Infirmary' Review: Found-Footage Horror at a Derelict Hospital",
"url": "https://www.wsj.com/arts-culture/television/infirmary-review-found-footage-horror-at-a-derelict-hospital-93218e06",
"source": "The Wall Street Journal",
"date": "2026-10-01T19:53:00Z",
"summary": "Shudder presents director Nicholas Pineda's film about security guards at an old institution with a chilling past.\n\nA \"found-footage\" horror film like \"Infirmary\" shows the strengths and weakness of the genre, such as it is, a subcategory that's seen plenty of winners and losers ",
"image": "https://opinion-images.wsj.net/im-07132437/social"
},
{
"title": "Here are Thursday's biggest analyst calls: Nvidia, Apple, Netflix, Micron, Amazon, Meta, Toll Brothers & more",
"url": "https://www.cnbc.com/2026/10/01/thursdays-biggest-analyst-calls-on-wall-street.html",
"source": "CNBC",
"date": "2026-10-01T12:20:41Z",
"summary": "Here are Thursday's biggest calls on Wall Street: Bank of America reiterates Micron as buy Bank of America said it sees a \"durable memory cycle\" following earnings. \" MU delivered another strong beat/raise, reinforcing our constructive view on memory's role in AI and increasing s",
"image": "https://image.cnbcfm.com/api/v1/image/108169493-17520658522025-07-09t125051z_974449402_rc20jfapo14t_rtrmadp_0_israel-tech-nvidia.jpeg?v=1754580511&w=1920&h=1080"
},
{
"title": "JPMorgan initiates Spyre stock with Overweight on IBD pipeline By Investing.com",
"url": "https://www.investing.com/news/analyst-ratings/jpmorgan-initiates-spyre-stock-with-overweight-on-ibd-pipeline-93CH-4926445",
"source": "Investing.com",
"date": "2026-10-01T07:32:55Z",
"summary": "Investing.com - JPMorgan initiated coverage on Spyre Therapeutics Inc. (NASDAQ:SYRE) with an Overweight rating and a price target of $110.00. The stock currently trades at $89.03, representing substantial upside to the target, following a remarkable 441% gain over the past year t",
"image": "https://content-media.investing.com/news/moved_LYNXMPEM3S10Z_1200_L.jpg"
},
{
"title": "Gain Therapeutics (NASDAQ:GANX) versus Spyre Therapeutics (NASDAQ:SYRE) Head to Head Comparison",
"url": "https://www.defenseworld.net/2026/09/28/gain-therapeutics-nasdaqganx-versus-spyre-therapeutics-nasdaqsyre-head-to-head-comparison.html",
"source": "Defense World",
"date": "2026-09-28 08:15:01",
"summary": "Spyre Therapeutics (NASDAQ: SYRE - Get Free Report) and Gain Therapeutics (NASDAQ: GANX - Get Free Report) are both healthcare companies, but which is the better business? We will compare the two companies based on the strength of their analyst recommendations, institutional owne",
"image": "https://images.financialmodelingprep.com/news/gain-therapeutics-nasdaqganx-versus-spyre-therapeutics-nasdaqsyre-head-to-20260928.jpg"
},
{
"title": "Spyre (SYRE) Clears Monotherapy Phase for IBD Portfolio, Setting Up Combination Tests",
"url": "https://finance.yahoo.com/healthcare/articles/spyre-syre-clears-monotherapy-phase-070453140.html",
"source": "Yahoo! Finance",
"date": "2026-09-17T07:04:53Z",
"summary": "On September 8, Spyre Therapeutics (NASDAQ:SYRE) announced that SPY003, its anti-IL-23 antibody, hit its primary endpoint in Part A of the Phase 2 SKYLINE trial, posting a 10.0-point reduction in Robart's Histopathology Index score at Week 12 with a p-value below 0.0001. That res",
"image": "https://s.yimg.com/lo/mysterio/api/ca6046554480eebc800db31e1bf44d1b4b0324c9bd85223aa7e612c2c5640f1c/lightyear_networkapi/resizefill_w1200%3Bquality_80%3Bformat_webp/https%3A%2F%2Fmedia.zenfs.com%2Fen%2Finsidermonkey.com%2F2da0d3e382ce14741f4fe4e0d26e6717.jpg"
},
{
"title": "California State Teachers Retirement System Buys 5,683,670 Shares of Spyre Therapeutics, Inc. $SYRE",
"url": "https://www.defenseworld.net/2026/09/15/california-state-teachers-retirement-system-buys-5683670-shares-of-spyre-therapeutics-inc-syre.html",
"source": "Defense World",
"date": "2026-09-15 03:26:06",
"summary": "California State Teachers Retirement System grew its stake in shares of Spyre Therapeutics, Inc. (NASDAQ: SYRE) by 9,594.0% in the undefined quarter, according to its most recent Form 13F filing with the Securities and Exchange Commission. The fund owned 5,742,912 shares of the c",
"image": "https://images.financialmodelingprep.com/news/california-state-teachers-retirement-system-buys-5683670-shares-of-20260915.jpg"
},
{
"title": "11,250 Shares in Spyre Therapeutics, Inc. $SYRE Acquired by VIRGINIA RETIREMENT SYSTEMS ET Al",
"url": "https://www.defenseworld.net/2026/09/14/11250-shares-in-spyre-therapeutics-inc-syre-acquired-by-virginia-retirement-systems-et-al.html",
"source": "Defense World",
"date": "2026-09-14 04:45:10",
"summary": "VIRGINIA RETIREMENT SYSTEMS ET Al purchased a new stake in Spyre Therapeutics, Inc. (NASDAQ: SYRE) during the second quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission. The institutional investor purchased 11,250 shares of ",
"image": "https://images.financialmodelingprep.com/news/11250-shares-in-spyre-therapeutics-inc-syre-acquired-by-20260914.jpg"
},
{
"title": "Spyre Therapeutics (SYRE) Reports SPY003 Endoscopic Improvement. Can Randomized Testing Confirm It?",
"url": "https://finance.yahoo.com/healthcare/articles/spyre-therapeutics-syre-reports-spy003-235903437.html",
"source": "Yahoo! Finance",
"date": "2026-09-10T23:59:03Z",
"summary": "Spyre Therapeutics, Inc. (NASDAQ:SYRE) reported September 8 results from 44 patients with moderately to severely active ulcerative colitis in the open-label Part A of the Phase 2 SKYLINE trial. At week 12, the mean Robarts Histopathology Index, a measure of tissue inflammation, d",
"image": "https://s.yimg.com/lo/mysterio/api/5e12db6d7f171dd5cf5ffa6917259265316b6f95dc255996f3a80e7e7c8a07c5/lightyear_networkapi/resizefill_w1200%3Bquality_80%3Bformat_webp/https%3A%2F%2Fmedia.zenfs.com%2Fen%2Finsidermonkey.com%2Fd15130425b806b509938ee3278c36175.jpg"
},
{
"title": "Spyre Therapeutics at Wells Fargo conference: betting on combination biologics By Investing.com",
"url": "https://www.investing.com/news/transcripts/spyre-therapeutics-at-wells-fargo-conference-betting-on-combination-biologics-93CH-4895949",
"source": "Investing.com",
"date": "2026-09-10T12:51:58Z",
"summary": "On Thursday, 10 September 2026, Spyre Therapeutics (SYRE) used the Wells Fargo 21st Annual Healthcare Conference to outline a broad autoimmune strategy built around optimized antibodies and combination therapy. Management said the company sees both promise and limits in its pipel",
"image": "https://content-media.investing.com/news/LYNXNPEB9606Q_L.jpg"
},
{
"title": "Spyre Therapeutics at Citi summit: bets on autoimmune combinations By Investing.com",
"url": "https://www.investing.com/news/transcripts/spyre-therapeutics-at-citi-summit-bets-on-autoimmune-combinations-93CH-4894060",
"source": "Investing.com",
"date": "2026-09-09T15:03:16Z",
"summary": "Spyre Therapeutics (SYRE) used Citi's Biopharma Back to School Summit 2026 on Wednesday, 09 September 2026, to lay out an ambitious plan for autoimmune drug development, centered on long-acting antibodies and combination therapies. Chief Executive Cameron Turtle said the company ",
"image": "https://content-media.investing.com/news/LYNXMPECBE0OL_L.jpg"
},
{
"title": "Baird reiterates Spyre stock Outperform rating on positive trial data By Investing.com",
"url": "https://www.investing.com/news/analyst-ratings/baird-reiterates-spyre-stock-outperform-rating-on-positive-trial-data-93CH-4893137",
"source": "Investing.com",
"date": "2026-09-09T10:29:05Z",
"summary": "Investing.com - Baird reiterated an Outperform rating and $116.00 price target on Spyre Therapeutics shares (NASDAQ:SYRE) on Wednesday. The stock has surged 442% over the past year to $90.79, though InvestingPro data suggests shares may be overvalued relative to its Fair Value es",
"image": "https://content-media.investing.com/news/moved_LYNXMPEM3T1K3_1200_L.jpg"
},
{
"title": "Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript",
"url": "https://seekingalpha.com/article/4944572-spyre-therapeutics-inc-syre-presents-at-citigroups-biopharma-back-to-school-summit-2026",
"source": "Seeking Alpha",
"date": "2026-09-09 14:17:09",
"summary": "Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript",
"image": "https://images.financialmodelingprep.com/news/spyre-therapeutics-inc-syre-presents-at-citigroups-biopharma-back-20260909.jpg"
}
],
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},
{
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},
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},
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},
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},
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},
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},
{
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},
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},
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},
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
"symbol": "SYRE",
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"action": "maintain"
},
{
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"gradingCompany": "Guggenheim",
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"newGrade": "Buy",
"action": "maintain"
},
{
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"action": "maintain"
},
{
"symbol": "SYRE",
"date": "2024-05-10",
"gradingCompany": "BTIG",
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"newGrade": "Buy",
"action": "maintain"
},
{
"symbol": "SYRE",
"date": "2024-03-26",
"gradingCompany": "Stifel",
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"newGrade": "Buy",
"action": "maintain"
},
{
"symbol": "SYRE",
"date": "2024-03-01",
"gradingCompany": "Wells Fargo",
"previousGrade": "Equal Weight",
"newGrade": "Overweight",
"action": "upgrade"
},
{
"symbol": "SYRE",
"date": "2023-12-18",
"gradingCompany": "Stifel",
"previousGrade": "Buy",
"newGrade": "Buy",
"action": "maintain"
}
]
},
"whale_insider": {
"insider": [
{
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"reportingName": "King-Jones Heidy",
"typeOfOwner": "officer: See Remarks",
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