IONS — Ionis Pharmaceuticals, Inc.

Summary

Table of Contents

Company

Data:

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  "symbol": "IONS",
  "price": 52.38,
  "marketCap": 8656452860,
  "beta": 0.365,
  "lastDividend": 0,
  "range": "40.03-86.74",
  "change": -1.01,
  "changePercentage": -1.89174,
  "volume": 3844531,
  "averageVolume": 2534582,
  "companyName": "Ionis Pharmaceuticals, Inc.",
  "currency": "USD",
  "cik": "0000874015",
  "isin": "US4622221004",
  "cusip": "462222100",
  "exchangeFullName": "NASDAQ Global Select",
  "exchange": "NASDAQ",
  "industry": "Biotechnology",
  "website": "https://www.ionis.com",
  "description": "Founded in 1989 and headquartered in Carlsbad, California, Ionis Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery and development of RNA-targeted therapies within the United States. Its commercial portfolio includes three key medications: SPINRAZA, prescribed for spinal muscular atrophy (SMA) in both children and adults; TEGSEDI, an injectable treatment targeting polyneuropathy associated with hereditary transthyretin-mediated amyloidosis in adult patients; and WAYLIVRA, which addresses familial chylomicronemia syndrome and familial partial lipodystrophy. Ionis also maintains a robust pipeline, with several drug candidates currently in Phase 3 clinical trials. These include Eplontersen, a monthly self-administered subcutaneous injection designed for all forms of TTR amyloidosis; Olezarsen, intended for individuals with severe hypertriglyceridemia (SHTG); Donidalorsen, for patients suffering from hereditary angioedema; ION363, aimed at amyotrophic lateral sclerosis (ALS); Pelacarsen, developed for those with established cardiovascular disease and elevated lipoprotein(a); and Tofersen, which works by inhibiting the production of superoxide dismutase 1. Beyond these late-stage assets, the company is actively researching treatments for metabolic, infectious, renal, and ophthalmic diseases, as well as various types of cancer. The firm engages in significant collaborations, notably a strategic partnership with Biogen Inc. Additionally, it holds licensing and collaboration agreements with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc.",
  "ceo": "Brett Monia",
  "sector": "Healthcare",
  "country": "US",
  "fullTimeEmployees": "1402",
  "phone": "760 931 9200",
  "address": "2855 Gazelle Court",
  "city": "Carlsbad",
  "state": "CA",
  "zip": "92010",
  "image": "https://images.financialmodelingprep.com/symbol/IONS.png",
  "ipoDate": "1991-05-17",
  "defaultImage": false,
  "isEtf": false,
  "isActivelyTrading": true,
  "isAdr": false,
  "isFund": false,
  "sec_filings": [
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      "date": "2026-07-17",
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Price / Quote

Data:

{
  "symbol": "IONS",
  "name": "Ionis Pharmaceuticals, Inc.",
  "price": 54.01,
  "changePercentage": 1.16127,
  "change": 0.62,
  "volume": 8616185,
  "dayLow": 50.15,
  "dayHigh": 54.055,
  "yearHigh": 86.74,
  "yearLow": 40.03,
  "marketCap": 8925830650,
  "priceAvg50": 72.297,
  "priceAvg200": 75.69155,
  "exchange": "NASDAQ",
  "open": 50.23,
  "previousClose": 53.39,
  "timestamp": 1784750401
}

Volume

Data:

{
  "volume": 8616185,
  "avgVolume": 2534582,
  "short_ratio": [
    {
      "symbol": "IONS",
      "file_date": "2026-07-22",
      "date": "20260722",
      "short_volume": 1633543,
      "short_exempt_volume": 480,
      "total_volume": 4543532,
      "short_volume_ratio": 0.3595,
      "signal": "Bullish"
    }
  ]
}

Fundamentals

Data:

{
  "symbol": "IONS",
  "marketCap": 8925830650,
  "enterpriseValueTTM": 10793403650,
  "evToSalesTTM": 10.20306453884686,
  "evToOperatingCashFlowTTM": -11.852716479963805,
  "evToFreeCashFlowTTM": -11.112819418547305,
  "evToEBITDATTM": 2.3536289953282443,
  "netDebtToEBITDATTM": 0.4072463243503503,
  "currentRatioTTM": 4.098495515573039,
  "incomeQualityTTM": 2.7883478319447126,
  "grahamNumberTTM": null,
  "grahamNetNetTTM": -5.952427308126206,
  "taxBurdenTTM": 1.0043392420011563,
  "interestBurdenTTM": 1.3092135989564042,
  "workingCapitalTTM": 2220354000,
  "investedCapitalTTM": 2597819000,
  "returnOnAssetsTTM": -0.09466258972182069,
  "operatingReturnOnAssetsTTM": -0.10117575699349207,
  "returnOnTangibleAssetsTTM": -0.09466258972182069,
  "returnOnEquityTTM": -0.5857481456770128,
  "returnOnInvestedCapitalTTM": -0.11143512163134524,
  "returnOnCapitalEmployedTTM": -0.12906740304487707,
  "earningsYieldTTM": -0.036674755095168564,
  "freeCashFlowYieldTTM": -0.10881418638611523,
  "capexToOperatingCashFlowTTM": -0.06658049893095637,
  "capexToDepreciationTTM": 1.928925935352507,
  "capexToRevenueTTM": 0.05731387642398467,
  "salesGeneralAndAdministrativeToRevenueTTM": 0.44217518591797206,
  "researchAndDevelopementToRevenueTTM": 0.8747734811539156,
  "stockBasedCompensationToRevenueTTM": 0.0984167077086833,
  "intangiblesToTotalAssetsTTM": 0,
  "averageReceivablesTTM": 69842000,
  "averagePayablesTTM": 27056000,
  "averageInventoryTTM": 7802500,
  "daysOfSalesOutstandingTTM": 25.423671774782843,
  "daysOfPayablesOutstandingTTM": 543.7814789377289,
  "daysOfInventoryOutstandingTTM": 116.08888507326007,
  "operatingCycleTTM": 141.51255684804292,
  "cashConversionCycleTTM": -402.26892208968604,
  "freeCashFlowToEquityTTM": -489388000,
  "freeCashFlowToFirmTTM": -882119986.5640337,
  "tangibleAssetValueTTM": 491414000,
  "netCurrentAssetValueTTM": -21610000,
  "grossProfitMarginTTM": 0.9834836211631228,
  "ebitMarginTTM": -0.2347874338640594,
  "ebitdaMarginTTM": 4.335035198452724,
  "operatingProfitMarginTTM": -0.333494350381289,
  "pretaxProfitMarginTTM": -0.3073869012789039,
  "continuousOperationsProfitMarginTTM": -0.3087207274315386,
  "netProfitMarginTTM": -0.3087207274315386,
  "bottomLineProfitMarginTTM": -0.3087207274315386,
  "receivablesTurnoverTTM": 14.356698876282504,
  "payablesTurnoverTTM": 0.6712255090280446,
  "inventoryTurnoverTTM": 3.1441425229440347,
  "fixedAssetTurnoverTTM": 2.802535334401865,
  "assetTurnoverTTM": 0.30662855231452807,
  "quickRatioTTM": 4.090740743324993,
  "solvencyRatioTTM": 1.5235968234492852,
  "cashRatioTTM": 0.24195252242911228,
  "priceToEarningsRatioTTM": -27.140703517587937,
  "priceToEarningsGrowthRatioTTM": 5.065716260836117,
  "forwardPriceToEarningsGrowthRatioTTM": 0.5442121026781375,
  "priceToBookRatioTTM": 18.120860903433766,
  "priceToSalesRatioTTM": 8.437637388347598,
  "priceToFreeCashFlowRatioTTM": -9.18997819320736,
  "priceToOperatingCashFlowRatioTTM": -9.778805965559993,
  "debtToAssetsRatioTTM": 0.591586185267172,
  "debtToEquityRatioTTM": 4.153227217783783,
  "debtToCapitalRatioTTM": 0.8059468450083084,
  "longTermDebtToCapitalRatioTTM": 0.7330219221113377,
  "financialLeverageRatioTTM": 7.020493921622094,
  "workingCapitalTurnoverRatioTTM": 0.4777195200401374,
  "operatingCashFlowRatioTTM": -1.270776495937013,
  "operatingCashFlowSalesRatioTTM": -0.8608207710101252,
  "freeCashFlowOperatingCashFlowRatioTTM": 1.0665804989309564,
  "debtServiceCoverageRatioTTM": 8.772193849727618,
  "interestCoverageRatioTTM": -3.9150603145010043,
  "shortTermOperatingCashFlowCoverageRatioTTM": -2.1054959537572255,
  "operatingCashFlowCoverageRatioTTM": -0.4461771308907501,
  "capitalExpenditureCoverageRatioTTM": -15.019412831931387,
  "dividendPaidAndCapexCoverageRatioTTM": -15.019412831931387,
  "dividendPayoutRatioTTM": 0,
  "dividendYieldTTM": 0,
  "revenuePerShareTTM": 6.416166284556692,
  "netIncomePerShareTTM": -1.9808035226900542,
  "interestDebtPerShareTTM": 12.925415772044106,
  "cashPerShareTTM": 11.639876511760496,
  "bookValuePerShareTTM": 2.9805427174690977,
  "tangibleBookValuePerShareTTM": 2.9805427174690977,
  "shareholdersEquityPerShareTTM": 2.9805427174690977,
  "operatingCashFlowPerShareTTM": -5.523169208001262,
  "capexPerShareTTM": 0.3677353615488191,
  "freeCashFlowPerShareTTM": -5.890904569550081,
  "netIncomePerEBTTTM": 1.0043392420011563,
  "ebtPerEbitTTM": 0.9217154681255137,
  "priceToFairValueTTM": 18.120860903433766,
  "debtToMarketCapTTM": 0.19961604357797222,
  "effectiveTaxRateTTM": -0.004339242001156311,
  "enterpriseValueMultipleTTM": 2.3536289953282443,
  "dividendPerShareTTM": 0,
  "revenue_history": [
    {
      "date": "2025",
      "revenue": 944000000
    }
  ],
  "dcf": {
    "symbol": "IONS",
    "date": "2026-07-22",
    "dcf": -86.3236191210017,
    "Stock Price": 52.935
  },
  "statements": {
    "income": [
      {
        "date": "2025-12-31",
        "symbol": "IONS",
        "reportedCurrency": "USD",
        "cik": "0000874015",
        "filingDate": "2026-02-26",
        "acceptedDate": "2026-02-26 16:25:52",
        "fiscalYear": "2025",
        "period": "FY",
        "revenue": 944000000,
        "costOfRevenue": 16000000,
        "grossProfit": 928000000,
        "researchAndDevelopmentExpenses": 916000000,
        "generalAndAdministrativeExpenses": 0,
        "sellingAndMarketingExpenses": 0,
        "sellingGeneralAndAdministrativeExpenses": 394000000,
        "otherExpenses": 0,
        "operatingExpenses": 1310000000,
        "costAndExpenses": 1326000000,
        "netInterestIncome": 7221000,
        "interestIncome": 97765000,
        "interestExpense": 90544000,
        "depreciationAndAmortization": 20255000,
        "ebitda": -286745000,
        "ebit": -307000000,
        "nonOperatingIncomeExcludingInterest": -75000000,
        "operatingIncome": -382000000,
        "totalOtherIncomeExpensesNet": 2000000,
        "incomeBeforeTax": -380000000,
        "incomeTaxExpense": 1000000,
        "netIncomeFromContinuingOperations": -381000000,
        "netIncomeFromDiscontinuedOperations": 0,
        "otherAdjustmentsToNetIncome": 0,
        "netIncome": -381000000,
        "netIncomeDeductions": 0,
        "bottomLineNetIncome": -381000000,
        "eps": -2.38,
        "epsDiluted": -2.38,
        "weightedAverageShsOut": 160000000,
        "weightedAverageShsOutDil": 160000000
      }
    ],
    "balance_sheet": [
      {
        "date": "2025-12-31",
        "symbol": "IONS",
        "reportedCurrency": "USD",
        "cik": "0000874015",
        "filingDate": "2026-02-26",
        "acceptedDate": "2026-02-26 16:25:52",
        "fiscalYear": "2025",
        "period": "FY",
        "cashAndCashEquivalents": 372260000,
        "shortTermInvestments": 2305176000,
        "cashAndShortTermInvestments": 2677000000,
        "netReceivables": 66000000,
        "accountsReceivables": 66000000,
        "otherReceivables": 0,
        "inventory": 10048000,
        "prepaids": 0,
        "otherCurrentAssets": 247000000,
        "totalCurrentAssets": 2990000000,
        "propertyPlantEquipmentNet": 362000000,
        "goodwill": 0,
        "intangibleAssets": 0,
        "goodwillAndIntangibleAssets": 0,
        "longTermInvestments": 52209000,
        "taxAssets": 0,
        "otherNonCurrentAssets": 119394999,
        "totalNonCurrentAssets": 533200999,
        "otherAssets": 0,
        "totalAssets": 3523836000,
        "totalPayables": 30795000,
        "accountPayables": 28082000,
        "otherPayables": 2713000,
        "accruedExpenses": 116236000,
        "shortTermDebt": 453146000,
        "capitalLeaseObligationsCurrent": 0,
        "taxPayables": 0,
        "deferredRevenue": 73761000,
        "otherCurrentLiabilities": 107629000,
        "totalCurrentLiabilities": 781567000,
        "longTermDebt": 1898796000,
        "capitalLeaseObligationsNonCurrent": 262382999,
        "deferredRevenueNonCurrent": 92001000,
        "deferredTaxLiabilitiesNonCurrent": 0,
        "otherNonCurrentLiabilities": 0,
        "totalNonCurrentLiabilities": 2253180000,
        "otherLiabilities": 0,
        "capitalLeaseObligations": 262382999,
        "totalLiabilities": 3034747000,
        "treasuryStock": 0,
        "preferredStock": 0,
        "commonStock": 163000,
        "retainedEarnings": -2631195000,
        "additionalPaidInCapital": 3145402000,
        "accumulatedOtherComprehensiveIncomeLoss": -25281000,
        "otherTotalStockholdersEquity": 0,
        "totalStockholdersEquity": 489089000,
        "totalEquity": 489089000,
        "minorityInterest": 0,
        "totalLiabilitiesAndTotalEquity": 3523836000,
        "totalInvestments": 2357385000,
        "totalDebt": 2614325000,
        "netDebt": 2242065000
      }
    ],
    "cash_flow": [
      {
        "date": "2025-12-31",
        "symbol": "IONS",
        "reportedCurrency": "USD",
        "cik": "0000874015",
        "filingDate": "2026-02-26",
        "acceptedDate": "2026-02-26 16:25:52",
        "fiscalYear": "2025",
        "period": "FY",
        "netIncome": -381387000,
        "depreciationAndAmortization": 22694000,
        "deferredIncomeTax": 0,
        "stockBasedCompensation": 133874000,
        "changeInWorkingCapital": -51215000,
        "accountsReceivables": 26129000,
        "inventory": -13674000,
        "accountsPayables": -15360000,
        "otherWorkingCapital": -48310000,
        "otherNonCashItems": 7451000,
        "netCashProvidedByOperatingActivities": -268583000,
        "investmentsInPropertyPlantAndEquipment": -51444000,
        "acquisitionsNet": 0,
        "purchasesOfInvestments": -1918562000,
        "salesMaturitiesOfInvestments": 1697870000,
        "otherInvestingActivities": -5640000,
        "netCashProvidedByInvestingActivities": -277776000,
        "netDebtIssuance": 483236000,
        "longTermNetDebtIssuance": 483236000,
        "shortTermNetDebtIssuance": 0,
        "netStockIssuance": 192604000,
        "netCommonStockIssuance": 192604000,
        "commonStockIssuance": 192604000,
        "commonStockRepurchased": 0,
        "netPreferredStockIssuance": 0,
        "netDividendsPaid": 0,
        "commonDividendsPaid": 0,
        "preferredDividendsPaid": 0,
        "otherFinancingActivities": 0,
        "netCashProvidedByFinancingActivities": 675840000,
        "effectOfForexChangesOnCash": 702000,
        "netChangeInCash": 130183000,
        "cashAtEndOfPeriod": 372260000,
        "cashAtBeginningOfPeriod": 242077000,
        "operatingCashFlow": -268583000,
        "capitalExpenditure": -51444000,
        "freeCashFlow": -320027000,
        "incomeTaxesPaid": 0,
        "interestPaid": 10782000
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    ]
  }
}

Technical

Data:

{
  "price": 54.01,
  "rsi": 25.6859395616422,
  "sma20": 68.465,
  "sma50": 72.297,
  "sma200": 75.69154999999999,
  "adx": 38.340996138598946,
  "atr": 3.99,
  "atr_pct": 7.39,
  "high_52w": 86.5,
  "low_52w": 25.51,
  "structure": {
    "ema8": 56.6881387776552,
    "ema21": 64.37603440277142,
    "ema50": 69.97517303035079,
    "ema200": 70.17622865488454,
    "checks": {
      "price_above_all": false,
      "ema_stacked": false,
      "ema21_rising": false,
      "ema50_rising": false,
      "adx_over_30": true,
      "higher_highs_lows": false,
      "near_21ema": false
    },
    "dist_21ema_pct": -16.1,
    "macd": {
      "macd": -6.312,
      "signal": -4.404,
      "histogram": -1.908
    },
    "bollinger": {
      "mid": 68.47,
      "upper": 94.43,
      "lower": 42.5,
      "width_pct": 75.86
    },
    "crossover": {
      "fresh_cross": false,
      "pre_compressed": true,
      "held_above_21": false,
      "candles_since": 20,
      "intraday_support": false
    },
    "momentum": {
      "roc10": -36.1,
      "checks": {
        "roc_over_5": false,
        "rsi_in_band": false,
        "macd_expanding": false,
        "top_quartile_3d": false,
        "no_big_down": false,
        "near_high": false
      },
      "volume": {
        "rvol": 1.91,
        "checks": {
          "rvol_over_2": false,
          "up_vol_beats_down": false,
          "obv_new_high": false,
          "surge_day": true,
          "pullback_declining_vol": false,
          "last_up_beats_down": true
        }
      }
    },
    "relative_strength": {
      "sector": "Healthcare",
      "sector_etf": "XLV",
      "sector_etf_ret10d": -2.55,
      "checks": {
        "beats_spy_all": false,
        "beats_sector_10d": false,
        "rs_line_at_high": false,
        "sector_top3": true
      }
    },
    "commodity": {},
    "universe": {
      "checks": {
        "price_over_20": true,
        "avg_vol_over_2m": true,
        "mcap_over_1b": true,
        "no_earnings_7d": false,
        "not_lev_etf_spac": true,
        "bidask_spread": null,
        "dollar_vol_over_10m": true
      },
      "avg_dollar_vol": 132761405.16000001,
      "avg_vol": 2534582
    },
    "options": {
      "checks": {
        "call_vol_2x": false,
        "ivr_under_40": false,
        "iv_contracting": false,
        "oi_calls_above_price": false
      },
      "vals": {
        "call_vol_mult": 1.1,
        "iv_rank": 51.0
      }
    }
  }
}

Levels & Bars

Data:

{
  "prior_day": {
    "high": 54.06,
    "low": 50.01,
    "close": 54.01,
    "date": "2026-07-22"
  },
  "woodie_pivots": {
    "PP": 53.02,
    "R1": 56.04,
    "S1": 51.98,
    "R2": 57.08,
    "S2": 48.97
  },
  "swing": {
    "high_20d": 86.74,
    "low_20d": 50.01,
    "high_60d": 86.74,
    "low_60d": 50.01
  },
  "orb": {
    "high": 52.14,
    "low": 50.01,
    "date": "2026-07-22"
  },
  "vwap": 52.5,
  "volume_profile": {
    "poc": 53.49,
    "vah": 68.03,
    "val": 50.81,
    "sessions": 20
  },
  "recent_daily": [
    {
      "d": "2026-06-16",
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      "h": 73.955,
      "l": 72.3,
      "c": 73.09,
      "v": 1801390.354453
    },
    {
      "d": "2026-06-17",
      "o": 73.09,
      "h": 75.12,
      "l": 72.55,
      "c": 74.31,
      "v": 1788351.530613
    },
    {
      "d": "2026-06-18",
      "o": 75,
      "h": 75.6601,
      "l": 73.495,
      "c": 74.12,
      "v": 2984374.708573
    },
    {
      "d": "2026-06-22",
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    },
    {
      "d": "2026-06-23",
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      "v": 1405415.746232
    },
    {
      "d": "2026-06-24",
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      "h": 79,
      "l": 76.035,
      "c": 76.52,
      "v": 2485706.994721
    },
    {
      "d": "2026-06-25",
      "o": 76.69,
      "h": 79.545,
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    },
    {
      "d": "2026-06-26",
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      "v": 3828331.226026
    },
    {
      "d": "2026-06-29",
      "o": 81,
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    },
    {
      "d": "2026-06-30",
      "o": 81.17,
      "h": 81.2393,
      "l": 79.21,
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    {
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    {
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      "h": 81.99,
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      "v": 2301899.318809
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    {
      "d": "2026-07-06",
      "o": 82.11,
      "h": 84.01,
      "l": 81.19,
      "c": 83.18,
      "v": 1847437.90406
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    {
      "d": "2026-07-07",
      "o": 84.42,
      "h": 86.67,
      "l": 82.95,
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      "v": 2646707.658643
    },
    {
      "d": "2026-07-08",
      "o": 85.56,
      "h": 86.74,
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      "c": 84.46,
      "v": 2280833.818344
    },
    {
      "d": "2026-07-09",
      "o": 67.775,
      "h": 70.35,
      "l": 64.1001,
      "c": 64.27,
      "v": 20447626.473416
    },
    {
      "d": "2026-07-10",
      "o": 64.27,
      "h": 64.44,
      "l": 58.2,
      "c": 58.25,
      "v": 11444106.608116
    },
    {
      "d": "2026-07-13",
      "o": 57.91,
      "h": 57.91,
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      "c": 56.75,
      "v": 5097949.592697
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    {
      "d": "2026-07-14",
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      "h": 56.455,
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      "c": 54.93,
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    {
      "d": "2026-07-15",
      "o": 54.48,
      "h": 54.885,
      "l": 53.51,
      "c": 54.73,
      "v": 3577545.839082
    },
    {
      "d": "2026-07-16",
      "o": 53.95,
      "h": 55.98,
      "l": 53.38,
      "c": 54.65,
      "v": 3805259.619675
    },
    {
      "d": "2026-07-17",
      "o": 54.1,
      "h": 54.685,
      "l": 53.76,
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      "v": 2572809.001736
    },
    {
      "d": "2026-07-20",
      "o": 54.47,
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      "v": 2167064.62999
    },
    {
      "d": "2026-07-21",
      "o": 52.75,
      "h": 54.13,
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      "v": 3074069.855537
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    {
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      "o": 51.155,
      "h": 54.06,
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      "v": 8732966.383182
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  ]
}

Analyst Ratings

Data:

{
  "estimates": [
    {
      "symbol": "IONS",
      "date": "2030-12-31",
      "revenueLow": 3028011816,
      "revenueHigh": 3956480748,
      "revenueAvg": 3324032520,
      "ebitdaLow": -1186163127,
      "ebitdaHigh": -907805747,
      "ebitdaAvg": -996553518,
      "ebitLow": -1299297999,
      "ebitHigh": -994391214,
      "ebitAvg": -1091603644,
      "netIncomeLow": 962849606,
      "netIncomeHigh": 1358251208,
      "netIncomeAvg": 1088913606,
      "sgaExpenseLow": 944006513,
      "sgaExpenseHigh": 1233464010,
      "sgaExpenseAvg": 1036293297,
      "epsAvg": 6.80571,
      "epsHigh": 8.48907,
      "epsLow": 6.01781,
      "numAnalystsRevenue": 7,
      "numAnalystsEps": 5
    },
    {
      "symbol": "IONS",
      "date": "2029-12-31",
      "revenueLow": 2417745252,
      "revenueHigh": 3159090230,
      "revenueAvg": 2654105840,
      "ebitdaLow": -947103394,
      "ebitdaHigh": -724846258,
      "ebitdaAvg": -795707772,
      "ebitLow": -1037437025,
      "ebitHigh": -793981260,
      "ebitAvg": -871601463,
      "netIncomeLow": 547515203,
      "netIncomeHigh": 772356804,
      "netIncomeAvg": 619200003,
      "sgaExpenseLow": 753751109,
      "sgaExpenseHigh": 984871240,
      "sgaExpenseAvg": 827438382,
      "epsAvg": 3.87,
      "epsHigh": 4.82723,
      "epsLow": 3.42197,
      "numAnalystsRevenue": 11,
      "numAnalystsEps": 11
    },
    {
      "symbol": "IONS",
      "date": "2028-12-31",
      "revenueLow": 2017534836,
      "revenueHigh": 2035889992,
      "revenueAvg": 2026712414,
      "ebitdaLow": -610365067,
      "ebitdaHigh": -604862144,
      "ebitdaAvg": -607613606,
      "ebitLow": -668580984,
      "ebitHigh": -662553199,
      "ebitAvg": -665567091,
      "netIncomeLow": -565684803,
      "netIncomeHigh": 655681604,
      "netIncomeAvg": 96101550,
      "sgaExpenseLow": 628982362,
      "sgaExpenseHigh": 634704727,
      "sgaExpenseAvg": 631843544,
      "epsAvg": 0.75031,
      "epsHigh": 4.09801,
      "epsLow": -3.53553,
      "numAnalystsRevenue": 15,
      "numAnalystsEps": 13
    },
    {
      "symbol": "IONS",
      "date": "2027-12-31",
      "revenueLow": 1238893619,
      "revenueHigh": 1574004188,
      "revenueAvg": 1381061740,
      "ebitdaLow": -471890512,
      "ebitdaHigh": -371423500,
      "ebitdaAvg": -414045869,
      "ebitLow": -516898886,
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      "ebitAvg": -453537087,
      "netIncomeLow": -392044802,
      "netIncomeHigh": -122027200,
      "netIncomeAvg": -296399390,
      "sgaExpenseLow": 386234835,
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      "sgaExpenseAvg": 430556866,
      "epsAvg": -1.84988,
      "epsHigh": -0.76267,
      "epsLow": -2.45028,
      "numAnalystsRevenue": 17,
      "numAnalystsEps": 10
    }
  ],
  "price_target": {
    "symbol": "IONS",
    "targetHigh": 130,
    "targetLow": 75,
    "targetConsensus": 94.58,
    "targetMedian": 89.5
  },
  "ratings": {
    "symbol": "IONS",
    "rating": "D+",
    "overallScore": 1,
    "discountedCashFlowScore": 1,
    "returnOnEquityScore": 1,
    "returnOnAssetsScore": 1,
    "debtToEquityScore": 1,
    "priceToEarningsScore": 1,
    "priceToBookScore": 1
  },
  "grades": [
    {
      "symbol": "IONS",
      "date": "2026-07-16",
      "gradingCompany": "Wolfe Research",
      "previousGrade": "Outperform",
      "newGrade": "Peer Perform",
      "action": "downgrade"
    },
    {
      "symbol": "IONS",
      "date": "2026-07-13",
      "gradingCompany": "RBC Capital",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-07-10",
      "gradingCompany": "Citigroup",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-07-10",
      "gradingCompany": "Morgan Stanley",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-07-10",
      "gradingCompany": "Canaccord Genuity",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-07-10",
      "gradingCompany": "Barclays",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-07-10",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-07-09",
      "gradingCompany": "Jefferies",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-07-09",
      "gradingCompany": "Needham",
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      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-06-25",
      "gradingCompany": "Leerink Partners",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-06-25",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-06-25",
      "gradingCompany": "Goldman Sachs",
      "previousGrade": "Neutral",
      "newGrade": "Neutral",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-06-17",
      "gradingCompany": "Leerink Partners",
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      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-06-15",
      "gradingCompany": "TD Cowen",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-06-01",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-04-30",
      "gradingCompany": "RBC Capital",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-04-30",
      "gradingCompany": "Barclays",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-04-30",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-04-23",
      "gradingCompany": "TD Cowen",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-04-21",
      "gradingCompany": "Morgan Stanley",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-04-09",
      "gradingCompany": "B of A Securities",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-03-26",
      "gradingCompany": "Barclays",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-03-25",
      "gradingCompany": "Needham",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-03-25",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-03-03",
      "gradingCompany": "Leerink Partners",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-02-27",
      "gradingCompany": "Piper Sandler",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-02-26",
      "gradingCompany": "Stifel",
      "previousGrade": "Hold",
      "newGrade": "Hold",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-02-26",
      "gradingCompany": "Needham",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-02-06",
      "gradingCompany": "Piper Sandler",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2026-01-05",
      "gradingCompany": "Wells Fargo",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-12-17",
      "gradingCompany": "RBC Capital",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-12-15",
      "gradingCompany": "Leerink Partners",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-12-09",
      "gradingCompany": "B of A Securities",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-11-10",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-11-04",
      "gradingCompany": "Piper Sandler",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-30",
      "gradingCompany": "Barclays",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-30",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-30",
      "gradingCompany": "Needham",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-30",
      "gradingCompany": "Raymond James",
      "previousGrade": "Strong Buy",
      "newGrade": "Strong Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-30",
      "gradingCompany": "Morgan Stanley",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-30",
      "gradingCompany": "RBC Capital",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-30",
      "gradingCompany": "TD Cowen",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-16",
      "gradingCompany": "Morgan Stanley",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-08",
      "gradingCompany": "Oppenheimer",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-08",
      "gradingCompany": "Needham",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-08",
      "gradingCompany": "JP Morgan",
      "previousGrade": "Neutral",
      "newGrade": "Overweight",
      "action": "upgrade"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-08",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-10-06",
      "gradingCompany": "Stifel",
      "previousGrade": "Hold",
      "newGrade": "Hold",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-26",
      "gradingCompany": "Goldman Sachs",
      "previousGrade": "Sell",
      "newGrade": "Neutral",
      "action": "upgrade"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-23",
      "gradingCompany": "Morgan Stanley",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-23",
      "gradingCompany": "Guggenheim",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-23",
      "gradingCompany": "Barclays",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-23",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-23",
      "gradingCompany": "B of A Securities",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-04",
      "gradingCompany": "RBC Capital",
      "previousGrade": "Outperform",
      "newGrade": "Outperform",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-03",
      "gradingCompany": "Goldman Sachs",
      "previousGrade": "Sell",
      "newGrade": "Sell",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-03",
      "gradingCompany": "BMO Capital",
      "previousGrade": "Market Perform",
      "newGrade": "Outperform",
      "action": "upgrade"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-03",
      "gradingCompany": "Citigroup",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-03",
      "gradingCompany": "Barclays",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-02",
      "gradingCompany": "Needham",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-02",
      "gradingCompany": "Jefferies",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-09-02",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-08-25",
      "gradingCompany": "Needham",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-08-25",
      "gradingCompany": "JP Morgan",
      "previousGrade": "Neutral",
      "newGrade": "Neutral",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-08-22",
      "gradingCompany": "Piper Sandler",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-08-22",
      "gradingCompany": "Wells Fargo",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-08-22",
      "gradingCompany": "Barclays",
      "previousGrade": "Overweight",
      "newGrade": "Overweight",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-08-22",
      "gradingCompany": "Citigroup",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-08-22",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-08-12",
      "gradingCompany": "UBS",
      "previousGrade": "Neutral",
      "newGrade": "Neutral",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-07-31",
      "gradingCompany": "Raymond James",
      "previousGrade": "Strong Buy",
      "newGrade": "Strong Buy",
      "action": "maintain"
    },
    {
      "symbol": "IONS",
      "date": "2025-07-31",
      "gradingCompany": "Morgan Stanley",
      "previousGrade": "Equal Weight",
      "newGrade": "Overweight",
      "action": "upgrade"
    },
    {
      "symbol": "IONS",
      "date": "2025-07-31",
      "gradingCompany": "HC Wainwright & Co.",
      "previousGrade": "Buy",
      "newGrade": "Buy",
      "action": "maintain"
    }
  ]
}

News

Data:

[
  {
    "title": "Zeotech at Noosa Mining Conference 2026: concrete pitch gains pace By Investing.com",
    "url": "https://www.investing.com/news/transcripts/zeotech-at-noosa-mining-conference-2026-concrete-pitch-gains-pace-93CH-4807163",
    "source": "Investing.com",
    "date": "2026-07-22T22:04:13Z",
    "summary": "Wednesday, 22 July 2026 -- Zeotech (ZEO) used its presentation at the Noosa Mining Conference 2026 to make a broad case for its kaolin-based AusPozz product, saying it could cut concrete emissions, lift strength and open a large new market. The company also pointed to near-term c"
  },
  {
    "title": "Raymond James sees potential for beats across biopharma coverage By Investing.com",
    "url": "https://www.investing.com/news/stock-market-news/raymond-james-sees-potential-for-beats-across-biopharma-coverage-93CH-4802511",
    "source": "Investing.com",
    "date": "2026-07-21T10:12:03Z",
    "summary": "Investing.com -- Raymond James issued an earnings preview for seven commercial-stage biopharmaceutical companies ahead of second-quarter 2026 results, outlining key metrics that could drive stock performance.\n\nFor Insmed (NASDAQ:INSM), the firm said Symphony data tracked favorabl"
  },
  {
    "title": "INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Ionis Pharmaceuticals, Inc. - IONS",
    "url": "https://www.globenewswire.com/news-release/2026/07/21/3330861/1087/en/INVESTOR-ALERT-Pomerantz-Law-Firm-Investigates-Claims-On-Behalf-of-Investors-of-Ionis-Pharmaceuticals-Inc-IONS.html",
    "source": "GlobeNewsWire",
    "date": "2026-07-21 13:27:00",
    "summary": "NEW YORK, July 21, 2026 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Ionis Pharmaceuticals, Inc. (\u201cIonis\u201d or the \u201cCompany\u201d) (NASDAQ: IONS).\u00a0 Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com\u00a0or 646-581-9980, ext.\u00a0"
  },
  {
    "title": "Amova Asset Management Americas Inc. Has $6.13 Million Stock Position in Ionis Pharmaceuticals, Inc. $IONS",
    "url": "https://www.defenseworld.net/2026/07/21/amova-asset-management-americas-inc-has-6-13-million-stock-position-in-ionis-pharmaceuticals-inc-ions.html",
    "source": "Defense World",
    "date": "2026-07-21 03:17:21",
    "summary": "Amova Asset Management Americas Inc. reduced its stake in shares of Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) by 12.7% in the undefined quarter, according to the company in its most recent Form 13F filing with the SEC. The firm owned 81,696 shares of the company's stock after se"
  },
  {
    "title": "1 Quantum Computing Stock That Could Be the Next Palantir",
    "url": "https://finance.yahoo.com/technology/ai/articles/1-quantum-computing-stock-could-091900613.html",
    "source": "Yahoo! Finance",
    "date": "2026-07-20T09:19:00Z",
    "summary": "Quantum computing harnesses the rules of quantum mechanics to process information differently than classical computers. Instead of bits locked as zeros or ones, quantum systems use qubits that can exist in superposition -- holding multiple states at once. In artificial intelligen"
  },
  {
    "title": "Cathie Wood Just Bet Big on This Biotech Stock",
    "url": "https://finance.yahoo.com/healthcare/articles/cathie-wood-just-bet-big-142000026.html",
    "source": "Yahoo! Finance",
    "date": "2026-07-18T14:20:00Z",
    "summary": "Cathie Wood's ARK Genomic Revolution ETF (NYSEMKT: ARKG) focuses on companies in the genomics sector, especially in healthcare. Since the beginning of July, Wood has, through this Ark Invest exchange-traded fund (ETF), bought $15.3 million worth of Ionis Pharmaceuticals (NASDAQ: "
  },
  {
    "title": "Ionis Pharmaceuticals: The Heartbreak Is Priced In",
    "url": "https://seekingalpha.com/article/4922630-ionis-pharmaceuticals-the-heartbreak-is-priced-ininitiating-buy",
    "source": "Seeking Alpha",
    "date": "2026-07-16 18:09:36",
    "summary": "The ATTR-CM and tominersen setbacks drove an excessive selloff without impairing Ionis's wholly owned core assets. Tryngolza is the main value driver, supported by strong triglyceride and pancreatitis data and a large sHTG market. Dawnzera's upcoming pipeline catalysts and $1.9B "
  },
  {
    "title": "Fusion research center coming to Madison's former Oscar Mayer plant",
    "url": "https://finance.yahoo.com/energy/articles/fusion-research-center-coming-madisons-120318326.html",
    "source": "Yahoo! Finance",
    "date": "2026-07-15T12:03:18Z",
    "summary": "A massive nuclear fusion research center is coming to Madison's former Oscar Mayer plant, a key step in Wisconsin's efforts to become a high tech energy hub.\n\nWith financial backing from state and local governments, Madison-based Realta Fusion will build a 200,000-square-foot res"
  },
  {
    "title": "Oligonucleotide CDMO Market to Reach USD 9.87 Billion by 2031 as RNA-Targeted Drug Pipelines Expand",
    "url": "https://www.globenewswire.com/news-release/2026/07/15/3327496/28124/en/Oligonucleotide-CDMO-Market-to-Reach-USD-9-87-Billion-by-2031-as-RNA-Targeted-Drug-Pipelines-Expand.html",
    "source": "GlobeNewswire Inc.",
    "date": "2026-07-15T08:10:00Z",
    "summary": "The global oligonucleotide contract development and manufacturing organization (CDMO) market is experiencing strong growth driven by expanding RNA-targeted medicine pipelines, increased outsourcing of complex synthesis and manufacturing, and rising demand for precision medicine. "
  },
  {
    "title": "Ionis Pharmaceuticals, Inc. (IONS) Faces Investor Scrutiny After Surprise Trial Failure Drives Stock Down 23% \u2013 HBSS",
    "url": "https://www.globenewswire.com/news-release/2026/07/15/3328095/32716/en/Ionis-Pharmaceuticals-Inc-IONS-Faces-Investor-Scrutiny-After-Surprise-Trial-Failure-Drives-Stock-Down-23-HBSS.html",
    "source": "GlobeNewsWire",
    "date": "2026-07-15 16:02:00",
    "summary": "SAN FRANCISCO, July 15, 2026 (GLOBE NEWSWIRE) -- Investors in Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) saw the price of their shares plunge $20.19 (-23%) on July 9, 2026 after the commercial stage biotech company and its partner (AstraZeneca) announced that a late-stage trial f"
  },
  {
    "title": "Biogen Shares Decline After Detailed Diranersen Alzheimer's Study Data",
    "url": "https://www.zacks.com/stock/news/2954096/biogen-shares-decline-after-detailed-diranersen-alzheimer-s-study-data?cid=CS-STOCKNEWSAPI-FT-analyst_blog|company_news_medical_sector-2954096",
    "source": "Zacks Investment Research",
    "date": "2026-07-15 11:55:43",
    "summary": "BIIB's Alzheimer's drug data presentation reaffirms a phase II setback as investors weigh plans to advance diranersen in phase III despite missed goals."
  },
  {
    "title": "Ionis to hold second quarter 2026 financial results webcast",
    "url": "https://www.businesswire.com/news/home/20260715218889/en/Ionis-to-hold-second-quarter-2026-financial-results-webcast/",
    "source": "Business Wire",
    "date": "2026-07-15 07:05:00",
    "summary": "CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that it will host a live webcast on Wednesday, July 29 at 8:30 a.m. Eastern Time to discuss its second quarter 2026 financial results and highlight progress on key programs.The webcast m"
  },
  {
    "title": "Morgan Stanley Raises its Price Target on Alnylam (ALNY)",
    "url": "https://finance.yahoo.com/markets/stocks/articles/morgan-stanley-raises-price-target-160956965.html",
    "source": "Yahoo! Finance",
    "date": "2026-07-14T16:09:56Z",
    "summary": "Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) is one of the 10 Best Growth Stocks With Highest Upside Potential.\n\nOn July 10, 2026, Morgan Stanley raised the firm's price target on Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) to $400 from $370 and kept an Equal Weight rating on the "
  },
  {
    "title": "3 Growth Stocks to Stash",
    "url": "https://finance.yahoo.com/markets/stocks/articles/3-growth-stocks-stash-111111116.html",
    "source": "Yahoo! Finance",
    "date": "2026-07-14T11:11:11Z",
    "summary": "Growth is oxygen. But when it evaporates, the consequences can be severe - ask anyone who bought Cisco in the Dot-Com Bubble or newer investors who lived through the 2020 to 2022 COVID cycle.\n\nLuckily for you, our job at StockStory is to help you avoid short-term fads by pointing"
  },
  {
    "title": "Ionis Begins Dosing in Phase I/II Dravet Syndrome Study",
    "url": "https://www.zacks.com/stock/news/2953231/ionis-begins-dosing-in-phase-i-ii-dravet-syndrome-study?cid=CS-STOCKNEWSAPI-FT-analyst_blog|company_news_medical_sector-2953231",
    "source": "Zacks Investment Research",
    "date": "2026-07-14 11:06:11",
    "summary": "IONS doses first patient in the phase I/II ASCEND study of ION337, marking a key step in developing a potential disease-modifying treatment for Dravet syndrome."
  },
  {
    "title": "Levi & Korsinsky Notifies Investors of a Pending Investigation Into Securities Claims Involving Ionis Pharmaceuticals (IONS)",
    "url": "https://www.globenewswire.com/news-release/2026/07/14/3327064/3080/en/Levi-Korsinsky-Notifies-Investors-of-a-Pending-Investigation-Into-Securities-Claims-Involving-Ionis-Pharmaceuticals-IONS.html",
    "source": "GlobeNewsWire",
    "date": "2026-07-14 10:20:00",
    "summary": "Ionis Pharmaceuticals (NASDAQ: IONS) investors absorbed a >20% share decline after the Phase-3 CARDIO-TTRansform trial missed its primary endpoint. Levi & Korsinsky is investigating potential securities law violations."
  },
  {
    "title": "Ionis Partner Biogen Presents Phase 2 CELIA Data at AAIC Demonstrating Meaningful Clinical Outcomes and Robust Tau Reduction with Diranersen in Early Alzheimer's Disease",
    "url": "https://www.gurufocus.com/news/8957868/ionis-partner-biogen-presents-phase-2-celia-data-at-aaic-demonstrating-meaningful-clinical-outcomes-and-robust-tau-reduction-with-diranersen-in-early-alzheimers-disease",
    "source": "GuruFocus",
    "date": "2026-07-14 10:00:00",
    "summary": "[url=\"]Ionis Pharmaceuticals, Inc.[/url] (Nasdaq: IONS) today announced that its partner, Biogen, shared data from the Phase 2 CELIA study evaluating diranerse"
  },
  {
    "title": "The Phase 3 Failure That Sent Biotech Winners and Losers in Opposite Directions",
    "url": "https://finance.yahoo.com/healthcare/articles/phase-3-failure-sent-biotech-162500505.html",
    "source": "Yahoo! Finance",
    "date": "2026-07-13T16:25:00Z",
    "summary": "When a late-stage clinical trial misses a primary endpoint, the market reaction rarely distributes evenly across the board. The fallout often reveals undeniable fundamental truths about single-asset exposure, pipeline diversification, and the competitive moats protecting establis"
  },
  {
    "title": "US quantum computing needs a national buyer",
    "url": "https://www.ft.com/content/328b6708-a1dc-4438-a25a-2622c301d212",
    "source": "Financial Times News",
    "date": "2026-07-13T14:47:39Z",
    "summary": "Washington's demand signal could do for the technology what early defence contracts did for silicon\n\nThe writer is a quantum scientist and professor at UCLA\n\nThree of the scientific breakthroughs foundational to quantum computing were born in American labs. The transistor, the tr"
  },
  {
    "title": "IONS Investor Alert: Levi & Korsinsky Notifies Investors of an Investigation Into Ionis Pharmaceuticals (IONS)",
    "url": "https://www.businesswire.com/news/home/20260713121445/en/IONS-Investor-Alert-Levi-Korsinsky-Notifies-Investors-of-an-Investigation-Into-Ionis-Pharmaceuticals-IONS/",
    "source": "Business Wire",
    "date": "2026-07-13 10:00:00",
    "summary": "NEW YORK--(BUSINESS WIRE)--Shares of Ionis Pharmaceuticals fell more than 20% in the early trading on July 9, 2026, after the Company announced that its late-stage Phase-3 CARDIO-TTRansform trial, partnered with AstraZeneca, failed to meet its primary endpoint. If you purchased I"
  },
  {
    "title": "Transthyretin Amyloidosis Treatment Market Size to Reach USD 35.10 Billion by 2035, Growing at a 14.64% CAGR | SNS Insider",
    "url": "https://www.globenewswire.com/news-release/2026/07/07/3323005/0/en/Transthyretin-Amyloidosis-Treatment-Market-Size-to-Reach-USD-35-10-Billion-by-2035-Growing-at-a-14-64-CAGR-SNS-Insider.html",
    "source": "GlobeNewswire Inc.",
    "date": "2026-07-07T10:42:00Z",
    "summary": "The transthyretin amyloidosis treatment market is projected to grow from USD 8.95 billion in 2025 to USD 35.10 billion by 2035 at a 14.64% CAGR. Growth is driven by increased ATTR-CM diagnosis rates, FDA approvals of gene-silencing therapies like vutrisiran and acoramidis, improv"
  },
  {
    "title": "Protein Synthesis Research Market to Reach $42.8 Billion by 2031, Driven by Surging CGT Investment",
    "url": "https://www.globenewswire.com/news-release/2026/05/18/3296974/0/en/Protein-Synthesis-Research-Market-to-Reach-42-8-Billion-by-2031-Driven-by-Surging-CGT-Investment.html",
    "source": "GlobeNewswire Inc.",
    "date": "2026-05-18T18:33:00Z",
    "summary": "The global protein synthesis research market is experiencing accelerating growth driven by increased investment in cell and gene therapy research, rising chronic disease prevalence, and expanding healthcare budgets. North America leads with 42.8% market share, while Asia-Pacific "
  },
  {
    "title": "Oligonucleotides Clinical Trial Drug Development Pipeline Expands with Contributions from 200+ Key Companies | DelveInsight",
    "url": "https://www.globenewswire.com/news-release/2026/05/14/3295246/0/en/Oligonucleotides-Clinical-Trial-Drug-Development-Pipeline-Expands-with-Contributions-from-200-Key-Companies-DelveInsight.html",
    "source": "GlobeNewswire Inc.",
    "date": "2026-05-14T17:00:00Z",
    "summary": "The oligonucleotides clinical trial landscape is expanding rapidly with 200+ companies developing 600+ pipeline drugs. Major players like Novartis, Alnylam Pharmaceuticals, Amgen, and WaVe Life Sciences are advancing promising therapies across various clinical stages. Approximate"
  },
  {
    "title": "Why Is Biogen Stock Falling Thursday?",
    "url": "https://www.benzinga.com/news/health-care/26/05/52569107/why-is-biogen-stock-falling-thursday?utm_source=benzinga_taxonomy&utm_medium=rss_feed_free&utm_content=taxonomy_rss&utm_campaign=channel",
    "source": "Benzinga",
    "date": "2026-05-14T15:57:54Z",
    "summary": "Biogen stock fell 4.97% after reporting Phase 2 results for its Alzheimer's drug diranersen, which missed its primary endpoint but showed cognitive benefits and tau biomarker reductions across all doses. The company plans to advance the therapy to registrational development. Sepa"
  },
  {
    "title": "GSK Targets China's Hepatitis B Market Through New Deal",
    "url": "https://www.benzinga.com/news/health-care/26/05/52457192/gsk-targets-chinas-hepatitis-b-market-through-new-deal?utm_source=benzinga_taxonomy&utm_medium=rss_feed_free&utm_content=taxonomy_rss&utm_campaign=channel",
    "source": "Benzinga",
    "date": "2026-05-11T16:03:51Z",
    "summary": "GSK entered an exclusive strategic collaboration with Sino Biopharmaceutical to accelerate bepirovirsen, an investigational hepatitis B treatment, in mainland China. The drug is under priority regulatory review in China and showed positive Phase 3 trial data. GSK will retain mark"
  }
]

Calendar / Earnings

Data:

[
  {
    "symbol": "IONS",
    "date": "2026-07-29",
    "epsActual": null,
    "epsEstimated": -1.09141,
    "revenueActual": null,
    "revenueEstimated": 189054600,
    "lastUpdated": "2026-07-23"
  },
  {
    "symbol": "IONS",
    "date": "2026-04-29",
    "epsActual": -0.56,
    "epsEstimated": -0.85,
    "revenueActual": 246000000,
    "revenueEstimated": 195564600,
    "lastUpdated": "2026-07-23"
  },
  {
    "symbol": "IONS",
    "date": "2026-02-25",
    "epsActual": -1.41,
    "epsEstimated": -1.23667,
    "revenueActual": 203000000,
    "revenueEstimated": 156065400,
    "lastUpdated": "2026-05-25"
  },
  {
    "symbol": "IONS",
    "date": "2025-10-29",
    "epsActual": -0.61,
    "epsEstimated": -1.15,
    "revenueActual": 156719000,
    "revenueEstimated": 153570100,
    "lastUpdated": "2026-03-03"
  },
  {
    "symbol": "IONS",
    "date": "2025-07-30",
    "epsActual": 0.86,
    "epsEstimated": 0.27,
    "revenueActual": 452049000,
    "revenueEstimated": 131748010,
    "lastUpdated": "2026-03-03"
  }
]

Short & Liquidity

Data:

{
  "borrow": [
    {
      "date": "2026-07-21",
      "fee_pct": 0.4027,
      "available": 550000,
      "rebate_pct": 3.2173,
      "high_fee": 0.4027,
      "low_fee": 0.4027,
      "utilization_signal": "Medium"
    },
    {
      "date": "2026-07-20",
      "fee_pct": 0.4027,
      "available": 700000,
      "rebate_pct": 3.2173,
      "high_fee": 0.4027,
      "low_fee": 0.4027,
      "utilization_signal": "Medium"
    },
    {
      "date": "2026-07-17",
      "fee_pct": 0.4027,
      "available": 450000,
      "rebate_pct": 3.2173,
      "high_fee": 0.4135,
      "low_fee": 0.4027,
      "utilization_signal": "Medium"
    },
    {
      "date": "2026-07-16",
      "fee_pct": 0.4135,
      "available": 600000,
      "rebate_pct": 3.2165,
      "high_fee": 0.4135,
      "low_fee": 0.4135,
      "utilization_signal": "Medium"
    },
    {
      "date": "2026-07-15",
      "fee_pct": 0.4135,
      "available": 800000,
      "rebate_pct": 3.2165,
      "high_fee": 0.4135,
      "low_fee": 0.4027,
      "utilization_signal": "Medium"
    }
  ],
  "short_interest": [
    {
      "symbol": "IONS",
      "file_date": "",
      "error": "Symbol not found in FINRA biweekly file",
      "days_to_cover": null
    }
  ],
  "ftd": {
    "symbol": "IONS",
    "periods": [
      {
        "file_period": "202603a",
        "settlement_date": "20260313",
        "quantity_fails": 755,
        "price": 72.34
      },
      {
        "file_period": "202603b",
        "settlement_date": "20260331",
        "quantity_fails": 4940,
        "price": 72.52
      },
      {
        "file_period": "202604a",
        "settlement_date": "20260413",
        "quantity_fails": 1892,
        "price": 75.17
      },
      {
        "file_period": "202604b",
        "settlement_date": "20260417",
        "quantity_fails": 1,
        "price": 75.26
      },
      {
        "file_period": "202606a",
        "settlement_date": "20260612",
        "quantity_fails": 7,
        "price": 73.82
      },
      {
        "file_period": "202606b",
        "settlement_date": "20260630",
        "quantity_fails": 42698,
        "price": 80.69
      }
    ],
    "trend": "rising",
    "trend_description": "FTD quantity increasing \u2014 settlement pressure building, potential squeeze precursor"
  }
}

Whales & Insiders

Data:

{
  "insider": [
    {
      "symbol": "IONS",
      "filingDate": "2026-07-17",
      "transactionDate": "2026-07-15",
      "reportingCik": "0001753652",
      "companyCik": "0000874015",
      "transactionType": "A-Award",
      "securitiesOwned": 3399,
      "reportingName": "Reikes Peter N",
      "typeOfOwner": "director",
      "acquisitionOrDisposition": "A",
      "directOrIndirect": "D",
      "formType": "4",
      "securitiesTransacted": 3399,
      "price": 0,
      "securityName": "Restricted Stock Unit",
      "url": "https://www.sec.gov/Archives/edgar/data/874015/000087401526000247/0000874015-26-000247-index.htm"
    },
    {
      "symbol": "IONS",
      "filingDate": "2026-07-17",
      "transactionDate": "2026-07-15",
      "reportingCik": "0001491435",
      "companyCik": "0000874015",
      "transactionType": "A-Award",
      "securitiesOwned": 3399,
      "reportingName": "HANTSON LUDWIG",
      "typeOfOwner": "director",
      "acquisitionOrDisposition": "A",
      "directOrIndirect": "D",
      "formType": "4",
      "securitiesTransacted": 3399,
      "price": 0,
      "securityName": "Restricted Stock Unit",
      "url": "https://www.sec.gov/Archives/edgar/data/874015/000087401526000246/0000874015-26-000246-index.htm"
    },
    {
      "symbol": "IONS",
      "filingDate": "2026-07-17",
      "transactionDate": "2026-07-15",
      "reportingCik": "0001248398",
      "companyCik": "0000874015",
      "transactionType": "M-Exempt",
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      "total_premium": "2490000.00",
      "iv": 0.333065755580807,
      "volume": 1000,
      "nbbo_bid": "22.30"
    },
    {
      "underlying_symbol": "IONS",
      "expires": "2026-09-18",
      "open_interest": 678,
      "option_type": "call",
      "delta": 0.324500274210097,
      "ask_volume": 261,
      "last_price": "2.40",
      "implied_volatility": "0.527210459595513",
      "gamma": 0.034958987540931,
      "avg_price": "1.7658015267175572519083969462",
      "bid_volume": 317,
      "nbbo_ask": "2.35",
      "strike": "60",
      "option_symbol": "IONS260918C00060000",
      "total_premium": "115660.00",
      "iv": 0.477704630547955,
      "volume": 655,
      "nbbo_bid": "1.80"
    },
    {
      "underlying_symbol": "IONS",
      "expires": "2026-08-21",
      "open_interest": 1000,
      "option_type": "call",
      "delta": 0.476405921867112,
      "ask_volume": 511,
      "last_price": "2.75",
      "implied_volatility": "0.514121875080575",
      "gamma": 0.0532057176904429,
      "avg_price": "2.1343814432989690721649484535",
      "bid_volume": 54,
      "nbbo_ask": "2.85",
      "strike": "55",
      "option_symbol": "IONS260821C00055000",
      "total_premium": "124221.00",
      "iv": 0.483207369541454,
      "volume": 582,
      "nbbo_bid": "2.45"
    },
    {
      "underlying_symbol": "IONS",
      "expires": "2026-09-18",
      "open_interest": 501,
      "option_type": "put",
      "delta": -0.117875518889747,
      "ask_volume": 78,
      "last_price": "0.87",
      "implied_volatility": "0.568274290608162",
      "gamma": 0.0163568639069642,
      "avg_price": "0.6368662674650698602794411175",
      "bid_volume": 417,
      "nbbo_ask": "1.45",
      "strike": "42.5",
      "option_symbol": "IONS260918P00042500",
      "total_premium": "31907.00",
      "iv": 0.560702429697894,
      "volume": 501,
      "nbbo_bid": "0.40"
    }
  ],
  "oi_changes": {
    "net_call_oi_change": -138,
    "net_put_oi_change": 6000,
    "top": [
      {
        "strike": "40",
        "oi_change": 3000,
        "type": "put"
      },
      {
        "strike": "52.5",
        "oi_change": 3000,
        "type": "put"
      },
      {
        "strike": "60",
        "oi_change": -145,
        "type": "call"
      },
      {
        "strike": "65",
        "oi_change": 8,
        "type": "call"
      },
      {
        "strike": "80",
        "oi_change": -1,
        "type": "call"
      }
    ]
  }
}

Market Environment

Data:

{
  "vix": 18.77,
  "sp500": 7443.28,
  "fed_funds": 3.64,
  "yield_curve_10y2y": 0.39,
  "hy_spread": 2.73,
  "treasury": {
    "date": "2026-07-22",
    "month1": 3.76,
    "month2": 3.82,
    "month3": 3.89,
    "month6": 4.05,
    "year1": 4.11,
    "year2": 4.31,
    "year3": 4.34,
    "year5": 4.41,
    "year7": 4.53,
    "year10": 4.67,
    "year20": 5.17,
    "year30": 5.15
  },
  "events": []
}

Intraday Patterns

Data:

{
  "days": 42,
  "patterns": [
    {
      "name": "VWAP Touch",
      "count": 42,
      "pct": 100
    },
    {
      "name": "9 EMA Touch",
      "count": 42,
      "pct": 100
    },
    {
      "name": "21 EMA Touch",
      "count": 42,
      "pct": 100
    },
    {
      "name": "Woodie Pivot Touch",
      "count": 40,
      "pct": 95
    },
    {
      "name": "ORB Breakout",
      "count": 39,
      "pct": 93
    },
    {
      "name": "PDH/PDL Touch",
      "count": 39,
      "pct": 93
    },
    {
      "name": "Open Retracement",
      "count": 30,
      "pct": 71
    },
    {
      "name": "Gap Fill",
      "count": 26,
      "pct": 62
    },
    {
      "name": "Darvas Box",
      "count": 24,
      "pct": 57
    },
    {
      "name": "High Vol Open",
      "count": 12,
      "pct": 29
    },
    {
      "name": "Power Hour",
      "count": 9,
      "pct": 21
    }
  ]
}